How cancer cells adapt to stress through amyloid bodies
Official title: Amyloid-bodies and the Evolution of Malignancies
Funded at University of Miami School of Medicine · NIH-10900631 · Data updated 2026-11-12
This study is looking at how cancer cells use special protein clusters called amyloid bodies to handle stress, and it aims to learn more about these clusters and their role in cancer, which could help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | August 7, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $378,919 |
| NIH project number | 5R01CA275828-02 |
| Project ID | NIH-10900631 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer who are interested in understanding the biological mechanisms of their disease.
✕Less likely to help
Patients with non-cancerous conditions or those not diagnosed with any malignancies may not receive direct benefits from this research.
What this research studies
This research investigates how cancer cells utilize a unique mechanism involving amyloid bodies to adapt to various stress conditions. By studying low complexity noncoding RNA from specific regions of the human genome, the research aims to understand how these RNA molecules can trigger the formation of amyloid bodies, which are protein aggregates that play a role in tumor development. The project employs advanced proteomic analysis to explore the composition and function of these amyloid bodies in both normal and cancerous cells, potentially revealing new insights into cancer biology and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic approaches that target the mechanisms of cancer cell adaptation and improve treatment outcomes.
How similar studies have gone: While the concept of amyloid bodies in cancer is relatively novel, preliminary findings suggest that similar mechanisms have been observed in other studies, indicating potential for further exploration.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Lee, Stephen — University of Miami School of Medicine
- Study coordinator: Lee, Stephen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.