How cancer cells adapt to nutrient shortages in lymphoid malignancies
Metabolic adaptation in lymphoid malignancies
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-10746796
This study is looking at how certain cancer cells, specifically lymphoid cancers, manage to survive when they don't have enough nutrients, like specific amino acids, and aims to find new ways to treat patients by targeting these weaknesses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-10746796 on ClinicalTrials.gov |
What this research studies
This research investigates how lymphoid cancer cells adapt to nutrient limitations, particularly focusing on the role of amino acids like asparagine and glutamine. By understanding the metabolic dependencies of these cancer cells, the research aims to identify new therapeutic strategies that could improve treatment outcomes for patients. The approach involves studying the stress response pathways that cancer cells utilize to survive in nutrient-depleted environments. This could lead to targeted therapies that exploit these vulnerabilities in cancer metabolism.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lymphoid malignancies, such as B-cell lymphomas, who may benefit from novel therapeutic strategies targeting metabolic adaptations.
Not a fit: Patients with non-lymphoid cancers or those who do not have metabolic vulnerabilities may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the metabolic weaknesses of lymphoid malignancies, improving patient outcomes.
How similar studies have performed: Other research has shown promise in targeting metabolic dependencies in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, JI — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: ZHANG, JI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.