How cancer cells adapt their metabolism to survive nutrient changes
Innovations and mechanisms in tumor subcellular metabolism
This study looks at how pancreatic cancer cells change the way they use nutrients to survive when food is scarce, with the hope that understanding these changes can help develop better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11134802 on NIH RePORTER |
What this research studies
This research investigates how cancer cells, particularly those in pancreatic cancer, adapt their metabolism in response to fluctuations in nutrient availability. By studying the mechanisms of nutrient acquisition and metabolic rewiring, the research aims to uncover how malignant cells exploit their environment to survive and thrive in challenging conditions. The approach involves examining cellular processes and biochemical reactions that allow these cells to scavenge nutrients, providing insights into potential therapeutic targets. Patients may benefit from a deeper understanding of cancer metabolism, which could lead to new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pancreatic cancer or other malignancies that exhibit metabolic adaptations.
Not a fit: Patients with non-cancerous conditions or those whose cancers do not involve significant metabolic adaptations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that target the metabolic adaptations of cancer cells, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown success in targeting metabolic pathways in cancer, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Abu-Remaileh, Monther — Stanford University
- Study coordinator: Abu-Remaileh, Monther
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.