How cancer affects communication between the nucleus and mitochondria in cells
Altered Communication between the nucleus and the mitochondria under oncogenic states
This study is looking at how cancer affects the way cells communicate between their nucleus and energy-producing parts, which could help us find new ways to treat cancer and improve patient care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10688189 on NIH RePORTER |
What this research studies
This research investigates how cancer alters the communication pathways between the nucleus and mitochondria, which are crucial for cell function and survival. By examining the structure and function of nuclear pore complexes (NPCs), the study aims to understand how these changes contribute to cancer development and progression. The research utilizes advanced biological assays to analyze the impact of oncogenic alterations on cellular communication, potentially leading to new therapeutic strategies. Patients may benefit from insights gained about how to target these communication pathways with anti-cancer drugs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers such as leukemia and sarcomas, where nuclear-mitochondrial communication may be affected.
Not a fit: Patients with non-malignant conditions or those whose cancers do not involve alterations in nuclear pore complexes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve the effectiveness of anti-cancer therapies by targeting the communication pathways disrupted in cancer.
How similar studies have performed: Previous research has shown success in targeting nucleocytoplasmic trafficking as a therapeutic strategy in cancer treatment, indicating that this approach has potential.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Rout, Michael P — Rockefeller University
- Study coordinator: Rout, Michael P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.