How calorie restriction may reduce blood clot risks in older adults
Preventive mechanisms of Age-associated Thrombosis
This study is looking at how eating fewer calories might help older adults with type 2 diabetes lower their chances of developing blood clots, which can lead to serious heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11003368 on NIH RePORTER |
What this research studies
This research investigates the effects of calorie restriction on reducing the risk of blood clots in older adults, particularly those with type 2 diabetes. By studying aged mice, the researchers aim to understand how calorie restriction can diminish prothrombotic effects linked to aging and identify potential drug targets. The study focuses on the role of mitochondrial function and oxidative stress in platelet activation, which contributes to increased clotting risks. The findings could lead to new strategies for preventing serious cardiovascular events in the elderly.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, especially those with type 2 diabetes or other age-related conditions that increase clotting risks.
Not a fit: Patients who are younger and do not have any risk factors for thrombosis or age-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures against life-threatening blood clots in older adults.
How similar studies have performed: Previous research has shown promising results in using calorie restriction and mitochondrial-targeted therapies to reduce thrombotic risks, indicating a potential for success in this approach.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Dayal, Sanjana — University of Iowa
- Study coordinator: Dayal, Sanjana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.