How calorie restriction may reduce blood clot risks in older adults
Official title: Preventive mechanisms of Age-associated Thrombosis
Funded at University of Iowa · NIH-11003368 · Data updated 2026-11-12
This study is looking at how eating fewer calories might help older adults with type 2 diabetes lower their chances of developing blood clots, which can lead to serious heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $558,382 |
| NIH project number | 5R01HL168630-02 |
| Project ID | NIH-11003368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, especially those with type 2 diabetes or other age-related conditions that increase clotting risks.
✕Less likely to help
Patients who are younger and do not have any risk factors for thrombosis or age-related conditions may not benefit from this research.
What this research studies
This research investigates the effects of calorie restriction on reducing the risk of blood clots in older adults, particularly those with type 2 diabetes. By studying aged mice, the researchers aim to understand how calorie restriction can diminish prothrombotic effects linked to aging and identify potential drug targets. The study focuses on the role of mitochondrial function and oxidative stress in platelet activation, which contributes to increased clotting risks. The findings could lead to new strategies for preventing serious cardiovascular events in the elderly.
Why it matters
Potential benefit: If successful, this research could lead to new preventive measures against life-threatening blood clots in older adults.
How similar studies have gone: Previous research has shown promising results in using calorie restriction and mitochondrial-targeted therapies to reduce thrombotic risks, indicating a potential for success in this approach.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Dayal, Sanjana — University of Iowa
- Study coordinator: Dayal, Sanjana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.