How calorie restriction and stress affect insulin-producing cells in older adults
Beta cell adaptation mechanisms during caloric restriction and ER stress
['FUNDING_R01'] · VANDERBILT UNIVERSITY · NIH-10997399
This study is looking at how the insulin-making cells in our bodies change when we eat differently or deal with stress, especially in older adults, to help find better ways to manage type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10997399 on ClinicalTrials.gov |
What this research studies
This research investigates how insulin-producing beta cells adapt to changes in diet and stress, particularly in older adults. It focuses on understanding the mechanisms behind beta cell function and identity, especially during caloric restriction and the stress associated with aging. By examining the genetic and functional changes in these cells, the study aims to uncover how they can better respond to metabolic demands. This could lead to new insights into managing type 2 diabetes in older populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 65 and older, particularly those at risk for or diagnosed with type 2 diabetes.
Not a fit: Patients under the age of 65 or those without any metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for type 2 diabetes, particularly in older adults, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding beta cell function under stress, indicating that this approach has potential for significant findings.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ARROJO E DRIGO, RAFAEL — VANDERBILT UNIVERSITY
- Study coordinator: ARROJO E DRIGO, RAFAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adult onset diabetes, Adult-Onset Diabetes Mellitus