How calorie restriction affects aging in fruit flies
Official title: Calorie Restriction and Hallmarks of Aging in Drosophila
Funded at University of Connecticut Sch of Med/dnt · NIH-10901041 · Data updated 2026-11-12
This study is looking at how eating less might affect aging by using fruit flies, and it hopes to find out how different diets can change the way our cells work as we get older, which could lead to new ways to help slow down aging.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $415,209 |
| NIH project number | 1R56AG082788-01 |
| Project ID | NIH-10901041 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research would be individuals interested in aging and metabolic health.
✕Less likely to help
Patients with acute or severe metabolic disorders may not benefit directly from this research.
What this research studies
This research investigates the effects of calorie restriction on aging by studying fruit flies, a common model organism. The team will explore how changes in diet influence metabolic processes and cellular functions related to aging. By shifting the flies between high and low-calorie diets, they aim to understand the relationship between nutrient sensing and mitochondrial dysfunction, which are key hallmarks of aging. The findings could help identify new therapeutic targets to slow down the aging process.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for delaying age-related decline in humans.
How similar studies have gone: Other research has shown promising results in understanding the effects of calorie restriction on aging, making this approach a continuation of established findings.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Rogina, Blanka — University of Connecticut Sch of Med/dnt
- Study coordinator: Rogina, Blanka
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.