How calorie restriction affects aging and heart health through mitochondrial DNA changes
Calorie Restriction, Mitochondrial DNA Heteroplasmy, Cardiometabolic Profiles, and Biological Aging
['FUNDING_R21'] · TUFTS UNIVERSITY BOSTON · NIH-10788975
This study is looking at how eating fewer calories might affect aging and heart health by checking changes in your body's energy-making DNA, and it could help you understand how adjusting your diet might improve your health over time.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10788975 on ClinicalTrials.gov |
What this research studies
This research investigates how calorie restriction (CR) may influence biological aging and cardiometabolic health by examining changes in mitochondrial DNA (mtDNA). The study utilizes existing blood samples from a previous trial to analyze mtDNA heteroplasmic mutations at multiple time points. By understanding the relationship between CR and mtDNA integrity, the research aims to uncover mechanisms that could enhance longevity and reduce disease risk. Patients may gain insights into how dietary changes could impact their health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the effects of calorie restriction on aging and those at risk for cardiometabolic diseases.
Not a fit: Patients who are not interested in dietary changes or those with severe metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide valuable insights into dietary interventions that promote healthier aging and reduce the risk of cardiometabolic diseases.
How similar studies have performed: Previous studies, such as the CALERIE trial, have shown promising results regarding the effects of calorie restriction on biological aging and health markers.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MA, JIANTAO — TUFTS UNIVERSITY BOSTON
- Study coordinator: MA, JIANTAO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.