How calmodulin affects sodium channels related to heart rhythm
Regulation and dysregulation of sodium channels by by calmodulin
This study is looking at how certain proteins in the heart, called sodium channels and calmodulin, work together and how changes in them can cause irregular heartbeats, which can be dangerous; the goal is to find new ways to help treat these heart rhythm problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10907713 on NIH RePORTER |
What this research studies
This research investigates the relationship between sodium channels and calmodulin, a protein that regulates these channels, in the context of cardiac arrhythmias. It focuses on how mutations in sodium channels and calmodulin can lead to irregular heartbeats, which are a major cause of sudden cardiac death. The study will assess how changes in the binding affinity of calmodulin to sodium channels can influence heart rhythm and potentially lead to arrhythmias. By understanding these mechanisms, the research aims to identify new targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known genetic mutations affecting sodium channels or calmodulin, particularly those experiencing arrhythmias.
Not a fit: Patients without genetic predispositions to arrhythmias or those with non-genetic causes of heart rhythm issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from life-threatening heart rhythm disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of sodium channels in arrhythmias, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Radwanski, Przemyslaw — Ohio State University
- Study coordinator: Radwanski, Przemyslaw
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.