How calcium signals affect neurotransmitter release in retinal cells
Dynamics of calcium signals control neurotransmitter release in retinal ribbon synapses
This study looks at how calcium signals help retinal cells release important chemicals for vision, aiming to understand these processes better to find ways to help people with age-related eye problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tennessee Health Sci Ctr NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-11011505 on NIH RePORTER |
What this research studies
This research investigates the role of calcium signals in controlling the release of neurotransmitters in retinal bipolar cells, which are crucial for vision. The study aims to understand how these calcium signals influence the dynamics of neurotransmitter release and the recruitment of vesicles that carry these neurotransmitters. By examining these processes during different stages of development and in disease conditions, the research seeks to uncover the mechanisms that sustain effective neurotransmission in the retina. This could lead to insights into age-related retinal degeneration and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing age-related retinal degeneration or related visual impairments.
Not a fit: Patients with retinal conditions unrelated to age or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for age-related retinal degeneration, improving vision and quality of life for affected individuals.
How similar studies have performed: While the specific focus on calcium signals in retinal bipolar cells is novel, similar research has shown promising results in understanding neurotransmitter dynamics in other neuronal contexts.
Where this research is happening
Memphis, United States
- University of Tennessee Health Sci Ctr — Memphis, United States (Active)
Researchers
- Principal investigator: Vaithianathan, Thirumalini — University of Tennessee Health Sci Ctr
- Study coordinator: Vaithianathan, Thirumalini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.