How calcium signaling in bone cells affects bone remodeling
Official title: Role of Ca2+ Signaling by 3D Osteocyte Networks in Mechanoadaptive Response of the Bone Multicellular Unit
Funded at Syracuse University · NIH-10981037 · Data updated 2026-11-12
This study is looking at how bone cells react to movement and talk to each other, which could help us understand better ways to treat bone diseases for people who are dealing with bone issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Syracuse University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $322,408 |
| NIH project number | 1R01AR083466-01A1 |
| Project ID | NIH-10981037 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting bone health, such as osteoporosis or other bone diseases.
✕Less likely to help
Patients with stable bone health and no history of bone diseases may not receive direct benefits from this research.
What this research studies
This research investigates how osteocytes, the most abundant cells in bone, respond to mechanical stimuli and communicate through a 3D network. Using a specialized chip, the study will visualize calcium signaling in these cells to understand how it influences the activities of bone-forming and bone-resorbing cells. The research aims to uncover the mechanisms behind bone adaptation in both healthy and injured states, focusing on how disruptions in these networks affect calcium signaling and bone remodeling. Patients may benefit from insights that could lead to improved treatments for bone diseases.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating bone diseases by enhancing our understanding of bone remodeling processes.
How similar studies have gone: While the specific approach using a BMU chip is novel, similar studies have shown promise in understanding cellular signaling in bone health.
Where this research is happening
-
Syracuse University
Syracuse, United States Active
Researchers
- Principal investigator: Soman, Pranav — Syracuse University
- Study coordinator: Soman, Pranav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.