How calcium signaling affects communication in pancreatic cells
Official title: Calcium-mediated paracrine signaling in beta cell cilia
Funded at Washington University · NIH-11033000 · Data updated 2026-11-12
This study is looking at how certain signals in pancreatic cells help them communicate with each other, which is important for making insulin and managing blood sugar, and it could lead to better treatments for diabetes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | March 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $153,266 |
| NIH project number | 1K08DK142012-01 |
| Project ID | NIH-11033000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes or metabolic disorders, particularly those affected by conditions related to pancreatic function.
✕Less likely to help
Patients without any metabolic disorders or those not affected by diabetes may not receive direct benefits from this research.
What this research studies
This research investigates the role of calcium-mediated signaling in the communication between pancreatic islet cells, which are crucial for insulin production and regulation of blood glucose levels. The principal investigator, Dr. Samantha Adamson, is focusing on the function of primary cilia in these cells, exploring how they contribute to cellular interactions and overall pancreatic health. By understanding these mechanisms, the research aims to uncover new insights into diabetes and related metabolic disorders. Patients may benefit from advancements in treatment strategies that arise from this work.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetes and better management of blood glucose levels.
How similar studies have gone: Previous research has shown promising results in understanding cellular communication in pancreatic islets, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Digruccio, Samantha Adamson — Washington University
- Study coordinator: Digruccio, Samantha Adamson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.