How calcium signaling affects brain development and disorders like autism
Calcium-Dependent Regulation of Neural Fate in Development and Disease
This study is looking at how changes in calcium channels in the brain might lead to conditions like autism, and it aims to help us understand how these changes affect brain development, which could lead to new treatments for those with neuropsychiatric disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10983808 on NIH RePORTER |
What this research studies
This research investigates the role of calcium channels and signaling pathways in the development of the brain, particularly focusing on how mutations in these channels may lead to neuropsychiatric disorders such as autism spectrum disorders (ASD). The study aims to understand how calcium signals influence the differentiation of neural progenitor cells into neurons and glia, which are essential for proper brain function. By examining the molecular mechanisms involved in calcium signaling, the research seeks to uncover the links between genetic mutations and developmental changes that contribute to ASD. Patients may benefit from insights gained into how calcium signaling dysfunction can be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with autism spectrum disorders or those with a family history of neuropsychiatric conditions linked to calcium signaling mutations.
Not a fit: Patients without any neuropsychiatric disorders or those not affected by calcium signaling mutations may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autism spectrum disorders by targeting calcium signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding the role of calcium signaling in neuropsychiatric disorders, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Panagiotakos, Georgia — Icahn School of Medicine at Mount Sinai
- Study coordinator: Panagiotakos, Georgia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.