How calcium channels in the heart are regulated by specific proteins during stress responses
Phosphorylation-dependent regulation of calcium channels by macromolecular complexes
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11001593
This study is looking at how stress affects heart cells and could help find new treatments for heart failure by understanding how certain proteins work, which might lead to better ways to keep your heart healthy and prevent dangerous heart rhythms.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11001593 on ClinicalTrials.gov |
What this research studies
This research investigates how the activation of certain proteins during stress responses affects calcium channels in heart cells. It focuses on understanding the mechanisms behind β-adrenergic signaling, which can enhance heart function in acute situations but may lead to harmful effects in chronic conditions like heart failure. By studying genetically modified mice, the researchers aim to identify specific targets for new therapies that could improve heart health and prevent dangerous arrhythmias. The ultimate goal is to develop treatments that can better manage heart failure and related cardiovascular disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with heart failure or those at risk of developing arrhythmias.
Not a fit: Patients with non-cardiovascular conditions or those without heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart function and reduce the risk of life-threatening arrhythmias in patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding calcium channel regulation, indicating that this approach could lead to significant advancements in cardiovascular treatment.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARX, STEVEN O — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: MARX, STEVEN O
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.