How calcium channels affect brain cell changes related to learning and memory
L-type Ca2+ Channel Spike Regulation of Spine Structural Plasticity and Excitation-Transcription Coupling
This study looks at how certain channels in the brain help with learning and memory by affecting brain cell changes and gene activity, which could help us understand conditions that impact these functions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11007280 on NIH RePORTER |
What this research studies
This research investigates the role of L-type calcium channels in the brain's hippocampus, which is crucial for learning and memory. It focuses on how these channels influence the structural changes in brain cells and the subsequent gene expression necessary for long-term memory. By examining the signaling pathways activated by these calcium channels, the research aims to understand their impact on synaptic function and plasticity. Patients may benefit from insights into how alterations in these pathways relate to various neurological and psychiatric conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neurological or psychiatric disorders such as Alzheimer's disease, ADHD, or autism spectrum disorders.
Not a fit: Patients with conditions unrelated to synaptic plasticity or calcium signaling may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions like Alzheimer's disease and ADHD by targeting calcium signaling pathways.
How similar studies have performed: Previous research has shown promising results in understanding calcium signaling in relation to synaptic plasticity, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Dell'acqua, Mark L — University of Colorado Denver
- Study coordinator: Dell'acqua, Mark L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.