How calcium balance affects cell health in sepsis
Calcium homeostasis and cellular fitness in sepsis
This study is looking at how calcium levels in your cells affect your health during and after a serious infection called sepsis, with the goal of finding ways to help people recover better and avoid future health problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10924025 on NIH RePORTER |
What this research studies
This research investigates the role of calcium homeostasis in cellular health during and after sepsis, a severe infection that can lead to organ failure. The study aims to understand how changes in mitochondrial function and calcium signaling can impact long-term health outcomes for sepsis survivors. By examining the mechanisms that lead to neurocognitive disorders and other complications, the research seeks to identify potential therapeutic targets to improve recovery and reduce the risk of future health issues. Patients may be monitored for changes in their cellular responses to sepsis and how these relate to their overall health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been hospitalized for sepsis and are experiencing ongoing health issues post-recovery.
Not a fit: Patients who have not experienced sepsis or those with unrelated chronic health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance recovery and reduce long-term complications for sepsis survivors.
How similar studies have performed: Previous research has shown promising results in understanding cellular mechanisms in sepsis, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Rosengart, Matthew Randall — Washington University
- Study coordinator: Rosengart, Matthew Randall
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.