How C1 inhibitor affects blood clotting and thrombosis
Official title: Regulation of coagulation and thrombosis by C1 inhibitor
Funded at Univ of North Carolina Chapel Hill · NIH-10772562 · Data updated 2026-11-12
This study is looking at how a natural protein called C1 inhibitor affects blood clotting in people with Hereditary Angioedema, a condition that can make them more likely to develop dangerous blood clots, to see if understanding this can help find better treatments to keep them safe.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | September 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $685,884 |
| NIH project number | 1R01HL171042-01 |
| Project ID | NIH-10772562 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Hereditary Angioedema or those with a known deficiency in C1 inhibitor.
✕Less likely to help
Patients without a history of blood clotting disorders or those not affected by Hereditary Angioedema may not benefit from this research.
What this research studies
This research investigates the role of C1 inhibitor, a natural protein in the body, in regulating blood clotting and the risk of venous thromboembolism, a serious condition where blood clots form in veins. The study focuses on patients with Hereditary Angioedema, a rare disorder caused by a deficiency in C1 inhibitor, who may have an increased risk of developing blood clots. By examining blood samples and using animal models, the researchers aim to understand how C1 inhibitor influences coagulation pathways and explore potential anticoagulant treatments that could mitigate these risks.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients at risk of venous thromboembolism, particularly those with Hereditary Angioedema.
How similar studies have gone: Previous studies have indicated that targeting the coagulation pathways in similar patient populations can yield promising results, suggesting that this approach may be effective.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Grover, Steven P. — Univ of North Carolina Chapel Hill
- Study coordinator: Grover, Steven P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.