How breathing in certain pollutants affects lung healing
Impact of particle and ozone inhalation co-exposure on alveolar epithelial regeneration
['FUNDING_R01'] · WEST VIRGINIA UNIVERSITY · NIH-10798211
This study is looking at how breathing in certain air pollutants, like carbon black particles and ozone, affects the healing of lung tissue after an injury, which could help us understand how to protect our lungs better in polluted environments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEST VIRGINIA UNIVERSITY (nih funded) |
| Locations | 1 site (MORGANTOWN, UNITED STATES) |
| Trial ID | NIH-10798211 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of inhaling a combination of carbon black particles and ozone on lung tissue regeneration, particularly after acute lung injury. By studying these co-exposures in a controlled environment, the researchers aim to understand the mechanisms that lead to lung damage and impaired healing. The study focuses on how these pollutants interact at a cellular level, particularly looking at the role of specific receptors in lung cells. The findings could help inform better public health guidelines regarding air quality and pollution exposure.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of acute lung injury or those living in areas with high levels of air pollution.
Not a fit: Patients with chronic lung diseases unrelated to environmental exposures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for protecting lung health in individuals exposed to air pollution.
How similar studies have performed: While the specific co-exposure scenario is less studied, similar research has shown that understanding the effects of combined pollutants can lead to significant advancements in public health.
Where this research is happening
MORGANTOWN, UNITED STATES
- WEST VIRGINIA UNIVERSITY — MORGANTOWN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUSSAIN, SALIK — WEST VIRGINIA UNIVERSITY
- Study coordinator: HUSSAIN, SALIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.