How breast cancer treatment affects heart health and aging
Epigenetics, accelerated aging, and cardiovascular health during breast cancer treatment
['FUNDING_R21'] · UNIVERSITY OF WASHINGTON · NIH-11109042
This study is looking at how breast cancer treatments might affect heart health and aging in women, and it aims to find out if staying active can help improve heart function and overall well-being during treatment.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11109042 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of breast cancer treatment on cardiovascular health and accelerated aging in women. It focuses on understanding how treatments can lead to declines in exercise capacity and heart function, potentially due to epigenetic changes associated with aging. By examining these relationships, the study aims to identify mechanisms that contribute to cardiovascular complications and explore lifestyle modifications, such as increased physical activity, that may help mitigate these effects. The use of accelerometers to track physical activity will provide valuable insights into how exercise can influence aging and heart health during treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are women currently receiving treatment for breast cancer who may be experiencing declines in exercise capacity or heart function.
Not a fit: Patients who are not undergoing breast cancer treatment or those with pre-existing severe cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted interventions that improve heart health and quality of life for women undergoing breast cancer treatment.
How similar studies have performed: Previous research has shown that physical activity can counteract the effects of accelerated aging, suggesting that this approach may be effective in breast cancer patients as well.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VASBINDER, ALEXI L — UNIVERSITY OF WASHINGTON
- Study coordinator: VASBINDER, ALEXI L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.