How breast cancer cells affect the brain environment for metastasis
Official title: PDGF-BB and the metastatic brain microenvironment
Funded at Ohio State University · NIH-10906359 · Data updated 2026-11-12
This study is looking at how a protein made by breast cancer cells affects the brain and helps the cancer spread, and it aims to find out if blocking this protein can lead to new treatments for people with breast cancer that has spread to the brain.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 11, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $440,127 |
| NIH project number | 5R37CA282660-02 |
| Project ID | NIH-10906359 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with breast cancer, particularly those at risk of developing brain metastases.
✕Less likely to help
Patients with breast cancer that has not metastasized or those with other types of cancer may not benefit from this research.
What this research studies
This research investigates the role of a specific protein, PDGF-BB, produced by breast cancer cells in influencing the brain's environment to promote cancer spread. It aims to understand how this protein interacts with various cell types in the brain, potentially leading to changes that support tumor growth. The study will utilize mouse models to explore the effects of inhibiting this protein on tumor development in the brain, providing insights into new treatment strategies for patients with breast cancer that has spread to the brain.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent or reduce breast cancer metastasis to the brain.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways in cancer treatment, indicating potential for success in this approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Sizemore, Gina Marie — Ohio State University
- Study coordinator: Sizemore, Gina Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.