How BRCA2 affects DNA replication after damage
Regulation of DNA replication kinetics by BRCA2 after DNA damage
['FUNDING_R01'] · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · NIH-10884882
This study is looking at how changes in the BRCA2 gene can affect how our cells fix DNA damage and how this might increase the risk of cancer, especially by exploring how BRCA2 works with another protein called MCM10 to keep DNA replication running smoothly.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS BIOMEDICAL AND HEALTH SCIENCES (nih funded) |
| Locations | 1 site (Newark, UNITED STATES) |
| Trial ID | NIH-10884882 on ClinicalTrials.gov |
What this research studies
This research investigates the role of the BRCA2 gene in regulating DNA replication, particularly after DNA damage. It focuses on understanding how mutations in BRCA2 can lead to increased cancer risk by affecting the mechanisms that control DNA repair and replication. The study will explore the interaction between BRCA2 and another protein, MCM10, to determine how this relationship influences the speed and accuracy of DNA replication following damage. By examining these processes, the research aims to uncover potential links between BRCA2 mutations and cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known BRCA2 mutations or those with a family history of breast, ovarian, or pancreatic cancers.
Not a fit: Patients without BRCA2 mutations or those not at risk for the cancers associated with BRCA2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer risks associated with BRCA2 mutations and inform new treatment strategies.
How similar studies have performed: Previous research has shown that understanding the mechanisms of DNA repair and replication can lead to significant advancements in cancer treatment, suggesting that this approach has potential for success.
Where this research is happening
Newark, UNITED STATES
- RUTGERS BIOMEDICAL AND HEALTH SCIENCES — Newark, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: XIA, BING — RUTGERS BIOMEDICAL AND HEALTH SCIENCES
- Study coordinator: XIA, BING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Breast Cancer 2 Gene, Breast Cancer Cell, Breast Cancer Model, Breast Cancer Type 2 Susceptibility Gene