How BRCA1 and 53BP1 control DNA repair in BRCA-related cancers
Project 2: BRCA1-dependent DNA End Resection and Regulation via the 53BP1 Axis
Researchers are looking at how BRCA1 and partner proteins control DNA repair in people with BRCA-deficient tumors to help prevent resistance to PARP inhibitor treatments.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11143728 on NIH RePORTER |
What this research studies
This project examines the molecular steps BRCA1 and BARD1 use to enable accurate DNA repair and how the 53BP1 pathway can block or permit that repair. Laboratory work will use cellular and tumor models to follow DNA end resection and the proteins that regulate it. The team will connect these molecular events to why some BRCA-deficient tumors stop responding to PARP inhibitors. Findings could point to markers or targets for future tests or therapies.
Who could benefit from this research
Good fit: People with BRCA1- or BRCA2-mutated cancers, particularly those being treated with or who have developed resistance to PARP inhibitors.
Not a fit: People without BRCA-related tumors or those not treated with PARP inhibitors are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: Could lead to ways to prevent or reverse PARP inhibitor resistance and improve treatment options for people with BRCA-mutant cancers.
How similar studies have performed: Prior studies showed BRCA loss makes tumors sensitive to PARP inhibitors and that disrupting the 53BP1 axis can restore repair and cause resistance, but the exact mechanisms targeted here remain to be clarified.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Burma, Sandeep — University of Texas Hlth Science Center
- Study coordinator: Burma, Sandeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.