How BRCA genes and 53BP1 control DNA repair
Admin Core: Regulation of BRCA-dependent Genome Repair via the 53BP1 Axis
['FUNDING_P01'] · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · NIH-11143720
This project looks at how BRCA proteins and the 53BP1 protein decide how cells fix dangerous DNA breaks, information that matters for people with BRCA-related cancer risk.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS HLTH SCIENCE CENTER (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-11143720 on ClinicalTrials.gov |
What this research studies
Multiple labs are working together to understand how BRCA1/2 and the protein 53BP1 influence whether cells use accurate or error-prone DNA repair. Researchers will use purified proteins, structural and biophysical tests, and cell models to watch protein interactions at broken DNA and measure repair outcomes. Shared cores will supply high-quality protein preparations and precise measurement tools to study these molecular events. The goal is to reveal mechanisms that could explain how BRCA-related cancers arise and why some therapies fail or succeed.
Who could benefit from this research
Good fit: People with inherited BRCA1 or BRCA2 mutations or a strong family history of hereditary breast or ovarian cancer would be the most relevant group for results from this work.
Not a fit: People with conditions unrelated to BRCA genes or DNA-repair defects are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the findings could point to new ways to prevent or treat BRCA-related cancers by influencing how damaged DNA is repaired.
How similar studies have performed: Prior basic research on BRCA proteins and 53BP1 has produced important insights and supported therapies like PARP inhibitors, but the specific regulatory details targeted here are still being worked out.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS HLTH SCIENCE CENTER — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUNG, PATRICK — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
- Study coordinator: SUNG, PATRICK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.