How brain support cells keep memory in sync with daily rhythms
Official title: Regulation of Synaptic Rhythmicity by Astrocytic Clock
Funded at Texas A&m University · NIH-11393006 · Data updated 2026-11-12
Scientists want to understand how brain support cells called astrocytes help the brain’s daily rhythm influence learning and memory, especially in relation to Alzheimer’s disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $328,915 |
| NIH project number | 5R01NS133047-04 |
| Project ID | NIH-11393006 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with Alzheimer’s disease or circadian-related cognitive issues may benefit from insights that improve diagnosis, prevention, or treatment strategies in the future.
✕Less likely to help
Healthy individuals without sleep-wake disturbances or neurodegenerative risk may have indirect relevance but may not directly benefit.
What this research studies
This project examines how the brain’s circadian clock, including astrocytes, affects synapses and memory. By studying cells and animal models, researchers aim to map how daily rhythms alter synaptic proteins and cognitive performance. The work could clarify why circadian disruption is linked to cognitive decline and Alzheimer’s disease and point to new ways to protect memory.
Why it matters
Potential benefit: If successful, the findings could lead to strategies that preserve memory and reduce cognitive decline related to circadian disruption and Alzheimer’s disease.
How similar studies have gone: Prior research shows circadian rhythms influence synaptic function and cognition, supporting potential relevance to human health.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Farhy, Isabella — Texas A&m University
- Study coordinator: Farhy, Isabella
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.