How brain support cells (astroglia) contribute to Fragile X syndrome
Astroglia-Mediated Pathogenic Mechanisms in Fragile X Syndrome (FXS)
['FUNDING_OTHER'] · TUFTS UNIVERSITY BOSTON · NIH-11358362
Researchers are looking at how changes in brain support cells and small RNA molecules may drive symptoms in people with Fragile X syndrome.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11358362 on ClinicalTrials.gov |
What this research studies
This project looks at how loss of the Fragile X protein (FMRP) changes the development and function of astroglia, the brain's support cells. The team is focusing on microRNAs that bind to the 3' untranslated regions of messenger RNAs and how those microRNAs control astroglial maturation after birth. They will use biochemical and genetic experiments in cells and animal models and examine molecular and structural changes in astroglia. The goal is to reveal pathways in astroglia that could be targeted to improve brain development and behavior in Fragile X.
Who could benefit from this research
Good fit: People with Fragile X syndrome (a confirmed FMR1 mutation) or families willing to provide clinical information or biological samples would be most relevant to this research.
Not a fit: Individuals without Fragile X or with unrelated causes of intellectual disability are unlikely to receive direct benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could identify new molecular targets for treatments that improve thinking, behavior, or sensory issues in people with Fragile X.
How similar studies have performed: Previous work has shown FMRP and certain microRNAs affect neurons and some astrocyte functions, but targeting astroglial microRNA pathways in Fragile X is a relatively new and largely untested approach.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, YONGJIE — TUFTS UNIVERSITY BOSTON
- Study coordinator: YANG, YONGJIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.