How brain structure variations affect blood flow and cognitive decline
Impact of cerebral anatomical variations on cerebral perfusion, cerebrovascular reactivity, and biomarkers of cognitive decline
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10611783
This study is looking at how differences in brain structure affect blood flow and how well the brain can adapt to changes in blood supply, especially in adults who might be experiencing memory problems like those seen in Alzheimer's disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10611783 on ClinicalTrials.gov |
What this research studies
This research investigates how variations in brain anatomy influence blood flow and the brain's ability to respond to changes in blood supply, which may lead to cognitive decline. The study focuses on adults with specific cerebral anatomical variations that may cause chronic low blood flow to the brain. By examining these individuals, researchers aim to understand the relationship between blood flow regulation and cognitive impairment, particularly in conditions like Alzheimer's disease. The methodology includes assessing cerebral perfusion and cerebrovascular reactivity through advanced imaging techniques.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have cerebral anatomical variations and may be at risk for cognitive impairment.
Not a fit: Patients without cerebral anatomical variations or those who do not exhibit cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential interventions for cognitive decline in individuals with specific brain anatomical variations.
How similar studies have performed: While there is limited research directly linking cerebral anatomical variations to cognitive decline in humans, previous studies have shown promising results in related areas, indicating potential for success.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BARNES, JILL NICOLE — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: BARNES, JILL NICOLE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.