How brain stimulation affects memory and learning in the hippocampus
Cellular mechanisms of hippocampal network neuroplasticity generated by brain stimulation
This study is exploring how brain stimulation might help improve memory and thinking skills for people with epilepsy who are having brain surgery, by looking at how the brain changes during this process.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10688285 on NIH RePORTER |
What this research studies
This research investigates how brain stimulation can enhance memory and cognitive abilities by targeting the hippocampal network, which is crucial for these functions. The study aims to understand the cellular mechanisms behind the neuroplastic changes induced by stimulation, particularly in patients undergoing neurosurgery for epilepsy. By examining the synchronization of brain activity during stimulation, researchers hope to identify optimal methods for improving memory outcomes. The approach includes both human participants and animal models to compare effects across species.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with intractable epilepsy who are undergoing neurosurgery.
Not a fit: Patients with memory disorders not related to hippocampal dysfunction or those who are not candidates for neurosurgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for memory-related disorders and enhance cognitive function in patients with epilepsy and other neurological conditions.
How similar studies have performed: Previous research has shown promising results in using brain stimulation to enhance memory, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
Chicago, United States
- Northwestern University at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Disterhoft, John F — Northwestern University at Chicago
- Study coordinator: Disterhoft, John F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.