How brain stem cells influence memory and emotional functions
Regulation of adult hippocampal function by the neural stem and progenitor cell secretome
This study is looking at how special brain cells called neural stem cells help with memory and emotions, and it could lead to new treatments for people who have trouble thinking or feeling after a brain injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11084270 on NIH RePORTER |
What this research studies
This research investigates the role of neural stem cells in the adult hippocampus, focusing on how these cells and their secreted proteins, particularly vascular endothelial growth factor (VEGF), contribute to cognitive and emotional functions. By analyzing the interactions between stem cells and other cell types in the brain, the study aims to uncover mechanisms that support memory and protect against brain injury. Patients may benefit from insights into how enhancing these processes could lead to new treatments for cognitive impairments following brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced an acquired brain injury.
Not a fit: Patients with chronic neurological conditions unrelated to brain injury may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory and emotional health in individuals with brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding the role of stem cells in brain function, suggesting that this approach could yield significant insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Kirby, Elizabeth Diana — Ohio State University
- Study coordinator: Kirby, Elizabeth Diana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.