How brain stem cells influence memory and emotional functions
Regulation of adult hippocampal function by the neural stem and progenitor cell secretome
This study is looking at how special cells in the brain help keep our memory and emotions healthy, especially by focusing on a protein called VEGF, and it’s for anyone interested in understanding how we might improve brain health and memory as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10994172 on NIH RePORTER |
What this research studies
This research investigates the role of neural stem and progenitor cells in the adult hippocampus, focusing on how these cells and their secreted proteins, particularly vascular endothelial growth factor (VEGF), contribute to brain health and cognitive-emotional functions. By analyzing the interactions between these stem cells and other cell types in the hippocampus, the study aims to uncover mechanisms that could help regenerate brain tissue and improve memory function. The research employs advanced techniques like RNA sequencing to explore the specific proteins involved in these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced an acquired brain injury.
Not a fit: Patients with chronic neurological conditions unrelated to brain injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance memory and emotional health in individuals with brain injuries.
How similar studies have performed: Previous research has shown promising results in understanding the role of stem cells in brain function, suggesting that this approach could yield significant insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Kirby, Elizabeth Diana — Ohio State University
- Study coordinator: Kirby, Elizabeth Diana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.