How brain signals affect the development of neural circuits
Genomic Mechanisms of BDNF Signaling in the Brain
This study looks at how a protein called BDNF helps shape brain connections during important growth stages, using mice to learn more about how it affects vision and could help us understand conditions like Alzheimer's disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10994590 on NIH RePORTER |
What this research studies
This research investigates the role of Brain-Derived Neurotrophic Factor (BDNF) in shaping neural circuits during critical developmental periods. By studying transgenic mice, the project aims to uncover how BDNF influences gene expression and synaptic connections in the brain, particularly in the visual cortex. The research focuses on understanding the mechanisms of synaptic plasticity, which is essential for processing sensory information. Patients may benefit from insights gained about BDNF's role in neurodegenerative conditions like Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurodegenerative conditions or those not affected by cognitive decline may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases, particularly Alzheimer's, by enhancing our understanding of synaptic plasticity.
How similar studies have performed: Previous research has shown promising results in understanding the role of BDNF in synaptic plasticity, indicating that this approach has potential for significant findings.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Gegenhuber, Jordan Bruno — Harvard Medical School
- Study coordinator: Gegenhuber, Jordan Bruno
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.