How brain signals affect nerve cell function
Neurotrophin-dependent regulation of voltage-gated sodium channels
This study is looking at how a special protein called BDNF affects the way nerve cells work, which could help us understand brain changes related to mental health conditions, and it might lead to new insights for patients dealing with these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10832489 on NIH RePORTER |
What this research studies
This research investigates how neurotrophins, specifically brain-derived neurotrophic factor (BDNF), influence the functioning of voltage-gated sodium channels in nerve cells. By examining the interactions between these channels and their regulatory proteins, the study aims to uncover the molecular mechanisms that contribute to brain plasticity and vulnerability to neuropsychiatric disorders. Patients may benefit from insights gained through various assays and imaging techniques that explore how changes in these signaling pathways affect neuronal behavior. The research employs a combination of in vitro experiments and electrophysiological assessments to gather data on these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with neuropsychiatric disorders or those at risk for such conditions.
Not a fit: Patients with neuropsychiatric disorders that do not involve the mechanisms being studied may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating neuropsychiatric disorders by targeting specific molecular pathways involved in brain function.
How similar studies have performed: Previous research has shown promising results in understanding the role of neurotrophins in neuronal function, suggesting that this approach may yield valuable insights.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Laezza, Fernanda — University of Texas Med Br Galveston
- Study coordinator: Laezza, Fernanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.