How brain signals affect connections and behavior in Alzheimer's disease
Official title: Neuromodulatory regulation of cortical functional connectivity
Funded at Yale University · NIH-11074145 · Data updated 2026-11-12
This study is looking at how certain brain signals affect thinking and behavior in people with Alzheimer's disease, hoping to learn more about how these changes can help us understand the condition better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $209,004 |
| NIH project number | 5R21EY036254-02 |
| Project ID | NIH-11074145 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with other forms of dementia not related to Alzheimer's may not benefit from this research.
What this research studies
This research investigates how neuromodulatory signals, particularly acetylcholine and norepinephrine, influence brain connectivity and behavior in individuals with Alzheimer's disease. By using advanced imaging techniques and electrophysiology, the study aims to observe how these signals change during different behavioral states. The goal is to understand the coordination between these signals and their impact on cognitive functions, which could lead to new insights into Alzheimer's disease progression.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for cognitive decline in Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding neuromodulatory signaling in other contexts, but this specific approach in Alzheimer's disease is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Cardin, Jessica a — Yale University
- Study coordinator: Cardin, Jessica a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.