How brain signals affect communication between nerve cells in the hippocampus
Presynaptic Modulation of Synaptic Inhibition onto Hippocampal Pyramidal Neurons
This study is looking at how a brain chemical called glutamate affects the way nerve cells talk to each other in the hippocampus, which is important for memory and learning, to help us understand how the brain controls signals that calm down or excite these cells.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Albany NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project ID | NIH-10863330 on NIH RePORTER |
What this research studies
This research investigates the role of presynaptic modulation in the hippocampus, focusing on how glutamate, a neurotransmitter, influences the communication between excitatory and inhibitory nerve cells. By examining the effects of glutamate spillover on different types of interneurons and their connections to CA1 pyramidal cells, the study aims to uncover the mechanisms that regulate synaptic inhibition. The research employs both in vitro and in vivo electrophysiological techniques to analyze these interactions and their impact on spatial information processing in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with epilepsy or seizure disorders, as they may benefit from advancements in understanding synaptic inhibition.
Not a fit: Patients with conditions unrelated to synaptic function or those not experiencing neurological disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of epilepsy and other neurological disorders, potentially informing better treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding synaptic modulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Albany, United States
- State University of New York at Albany — Albany, United States (Active)
Researchers
- Principal investigator: Scimemi, Annalisa — State University of New York at Albany
- Study coordinator: Scimemi, Annalisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.