How brain signals affect cocaine addiction and relapse
Nitrergic interneurons and cue-induced cocaine seeking
This study is looking at how certain brain cells affect cravings and relapse in people who are trying to overcome cocaine addiction, using animal models to learn more about how brain chemicals influence these behaviors, which could help develop better treatments for those in recovery.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11088280 on NIH RePORTER |
What this research studies
This research investigates the role of specific brain cells in cocaine addiction and the potential for relapse when exposed to drug-related cues. By studying animal models, the researchers aim to understand how the release of certain neurotransmitters, particularly nitric oxide, influences brain activity and behavior related to cocaine seeking. The study focuses on the nucleus accumbens, a key brain region involved in addiction, to identify the mechanisms that lead to increased cravings and relapse. The findings could provide insights into new treatment strategies for individuals struggling with cocaine addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine addiction who are at risk of relapse.
Not a fit: Patients who are not addicted to cocaine or those who have not previously experienced addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that reduce the risk of relapse in individuals recovering from cocaine addiction.
How similar studies have performed: Previous research has shown promising results in understanding the neurobiological mechanisms of addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Scofield, Michael David — Medical University of South Carolina
- Study coordinator: Scofield, Michael David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.