How brain signals affect balance and movement responses
Modulation of vestibular afferent properties by cholinergic and GABAergic inputs: from neural mechanisms to behavioral outcomes
This study is looking at how signals from the brain help balance and movement by affecting special receptors, and it's for anyone interested in understanding how the brain helps us stay steady, especially after an injury.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11094082 on NIH RePORTER |
What this research studies
This research investigates how signals from the brain influence the function of vestibular receptors, which are crucial for balance and movement. By examining the effects of cholinergic and GABAergic inputs on these receptors, the study aims to uncover the mechanisms that regulate their activity. Using both in vitro and in vivo mouse models, researchers will analyze how different receptor types respond to specific chemical signals, providing insights into the neural pathways involved in balance. This could lead to a better understanding of how the brain compensates for balance issues after injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing balance disorders or vestibular dysfunction.
Not a fit: Patients with stable balance and no vestibular issues are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for balance disorders and related conditions.
How similar studies have performed: Previous research has shown promise in understanding vestibular mechanisms, but this specific approach is relatively novel.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Sadeghi Ghandehari, Soroush — Johns Hopkins University
- Study coordinator: Sadeghi Ghandehari, Soroush
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.