How brain signals affect aging and cancer
The role of AgRP/Auga-ALK pathway in FGF21's brain action on aging
This research explores how specific brain cells influence aging and may protect against cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11141110 on NIH RePORTER |
What this research studies
Our bodies adapt to calorie restriction through particular brain circuits, especially those involving AgRP neurons. We've found that a hormone called FGF21 helps control these neurons, which in turn affects how our brain regulates behavior and body functions. Surprisingly, when these AgRP circuits are altered, mice live shorter lives but have much less cancer. This project aims to uncover the hidden ways these brain cells communicate to influence both metabolism and cancer development.
Who could benefit from this research
Good fit: Patients interested in the fundamental mechanisms of aging, metabolism, and cancer prevention may find this research relevant.
Not a fit: Patients seeking immediate new treatments or clinical interventions would not directly benefit from this early-stage basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to slow aging and prevent cancer by targeting specific brain pathways.
How similar studies have performed: This research uncovers a previously unknown signaling pathway linking brain cells to cancer development, suggesting a novel approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Horvath, Tamas L — Yale University
- Study coordinator: Horvath, Tamas L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.