How brain signaling affects energy balance and eating behavior
Dorsal raphe nucleus melanocortin signaling regulates energy homeostasis
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10876272
This study is looking at how certain brain cells help control hunger and energy use, which could lead to better ways to manage weight and related health issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10876272 on ClinicalTrials.gov |
What this research studies
This research investigates how specific neurons in the dorsal raphe nucleus of the brain regulate energy balance and feeding behavior. By examining the role of GABAergic MC4R neurons, the study aims to understand how these neurons influence food intake and energy expenditure. The researchers will use advanced techniques, including DREADD technology, to manipulate neuron activity in animal models, providing insights into the mechanisms that control appetite and metabolism. This could lead to new strategies for managing weight and metabolic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with obesity or metabolic disorders who may benefit from new therapeutic approaches.
Not a fit: Patients who do not have issues related to weight management or metabolic disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for obesity and related metabolic disorders by targeting brain signaling pathways that control appetite.
How similar studies have performed: Previous studies have shown promising results in understanding brain signaling related to appetite, indicating that this research builds on established findings in the field.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIANO, SABRINA — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: DIANO, SABRINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.