How brain networks shape the detail of our memories

Brain networks predicting variability in episodic memory quality

NIH-funded research Boston College · NIH-11097245

Using brain scans and memory tests, researchers want to learn why some memories are vivid and detailed while others are vague to help people with memory difficulties.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBoston College NIH-funded
Lab location1 site (Chestnut Hill, United States)
Project IDNIH-11097245 on NIH RePORTER

What this research studies

You would take part in memory tasks while researchers record brain activity with MRI to see how different brain regions work together when you recall people, places, and objects from past events. The team focuses on a set of posterior medial brain areas and the hippocampus to understand how links between regions support both the general structure and the specific details of memories. They will measure how connections among these regions predict how accurately and richly event features are remembered. The work seeks brain-based patterns that explain why memory quality varies from moment to moment.

Who could benefit from this research

Good fit: Adults who can safely undergo MRI, follow instructions for memory tasks, and are willing to recall or view events—this may include healthy volunteers and people with memory complaints or affective disorders.

Not a fit: People who cannot have an MRI (for example, due to implanted metal devices), have severe cognitive impairment that prevents task participation, or are unable to travel to the research site are unlikely to participate or benefit directly.

Why it matters

Potential benefit: If successful, this work could help identify brain patterns tied to clearer or poorer memories, eventually guiding new ways to diagnose or improve memory problems.

How similar studies have performed: Prior brain-imaging work has linked the hippocampus and parietal regions to memory, but applying network-level analyses to predict the detailed quality of remembered events is a newer approach.

Where this research is happening

Chestnut Hill, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Affective Disorders
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.