How brain lipoproteins affect Alzheimer's disease and memory loss
Official title: The impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease
Funded at Battelle Pacific Northwest Laboratories · NIH-10884814 · Data updated 2026-11-12
This study is looking at how certain proteins in the brain might affect the buildup of a harmful substance linked to Alzheimer's disease, and if you have Alzheimer's, you could help by providing samples to support this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $805,738 |
| NIH project number | 1R01NS125591-01A1 |
| Project ID | NIH-10884814 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are individuals aged 65 and older, particularly those with a family history of Alzheimer's or carrying the APOE4 gene variant.
✕Less likely to help
Patients under 65 years of age or those without any risk factors for Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of brain lipoproteins in the metabolism of amyloid beta, a protein associated with Alzheimer's disease. By utilizing a novel fluorescent lipoprotein profiling technology, the study aims to analyze the composition and structure of these lipoproteins in cerebrospinal fluid. The researchers will focus on how different forms of apolipoprotein E (APOE), particularly the APOE4 variant, influence the development of Alzheimer's pathology. Patients may have the opportunity to contribute samples that help deepen the understanding of these mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets.
How similar studies have gone: Previous research has shown promising results in understanding the role of lipoproteins in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Battelle Pacific Northwest Laboratories
Richland, United States Active
Researchers
- Principal investigator: Melchior, John — Battelle Pacific Northwest Laboratories
- Study coordinator: Melchior, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.