How brain lipoproteins affect Alzheimer's disease and memory loss
The impact of brain lipoprotein structure and composition on amyloid beta metabolism and Alzheimer's disease
This study is looking at how certain proteins in the brain might affect the buildup of a harmful substance linked to Alzheimer's disease, and if you have Alzheimer's, you could help by providing samples to support this important research.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Battelle Pacific Northwest Laboratories NIH-funded |
| Lab location | 1 site (Richland, United States) |
| Project ID | NIH-10884814 on NIH RePORTER |
What this research studies
This research investigates the role of brain lipoproteins in the metabolism of amyloid beta, a protein associated with Alzheimer's disease. By utilizing a novel fluorescent lipoprotein profiling technology, the study aims to analyze the composition and structure of these lipoproteins in cerebrospinal fluid. The researchers will focus on how different forms of apolipoprotein E (APOE), particularly the APOE4 variant, influence the development of Alzheimer's pathology. Patients may have the opportunity to contribute samples that help deepen the understanding of these mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals aged 65 and older, particularly those with a family history of Alzheimer's or carrying the APOE4 gene variant.
Not a fit: Patients under 65 years of age or those without any risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease mechanisms and potential therapeutic targets.
How similar studies have performed: Previous research has shown promising results in understanding the role of lipoproteins in neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Richland, United States
- Battelle Pacific Northwest Laboratories — Richland, United States (Active)
Researchers
- Principal investigator: Melchior, John — Battelle Pacific Northwest Laboratories
- Study coordinator: Melchior, John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.