How brain injuries affect aging and neurodegenerative diseases
Contributions of astrocyte RelA signaling in aging-related neurodegenerative sequelae following TBI
['FUNDING_R01'] · UNIVERSITY OF KENTUCKY · NIH-11001167
This study is looking at how certain brain cells change as we age and after a head injury, to see how these changes might increase the risk of developing diseases like Alzheimer's, especially in older adults, with the hope of finding new ways to help those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-11001167 on ClinicalTrials.gov |
What this research studies
This research investigates the role of a specific signaling pathway in astrocytes, a type of brain cell, in the context of aging and traumatic brain injury (TBI). It aims to understand how TBI increases the risk of developing neurodegenerative diseases like Alzheimer's Disease, particularly in older adults. The study uses an aging model to explore the cellular mechanisms that contribute to the brain's vulnerability after injury, focusing on neuroinflammation and memory impairment. By examining these processes, the research seeks to identify potential therapeutic targets for improving outcomes in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have suffered a traumatic brain injury and are at risk for developing Alzheimer's Disease or related dementias.
Not a fit: Patients who have not experienced a traumatic brain injury or are not in the aging population may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating neurodegenerative diseases in older adults who have experienced traumatic brain injuries.
How similar studies have performed: Previous research has shown that understanding the cellular responses to traumatic brain injury can lead to significant advancements in treating neurodegenerative diseases, suggesting this approach has potential for success.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MORGANTI, JOSH — UNIVERSITY OF KENTUCKY
- Study coordinator: MORGANTI, JOSH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.