How brain immune cells interact with neurons during fetal brain development.
Gene regulatory networks influencing neuron-microglia interactions in fetal brain development.
This study is looking at how brain immune cells called microglia help shape the brain's development during pregnancy, which could help us understand how problems in this process might lead to brain disorders later on.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11121925 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, the immune cells in the brain, during the critical periods of fetal brain development in the first and second trimesters. It aims to understand how these cells interact with neurons and influence the formation of neural networks, which is essential for healthy brain function. By using advanced models that mimic early human brain development, the study will analyze the molecular mechanisms of neuron-microglia interactions. This could provide insights into how dysfunction in these processes may lead to brain disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are expectant mothers, particularly those in their first or second trimester, who may have concerns about fetal brain development.
Not a fit: Patients who are not pregnant or those whose pregnancies are outside the first and second trimesters may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating brain disorders that arise from developmental issues.
How similar studies have performed: Other research has shown promising results in understanding immune cell interactions in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Han, Claudia Z — Washington University
- Study coordinator: Han, Claudia Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.