How Brain Immune Cells and Blood Vessels Work Together in Brain Health
Microglial-Neurovascular Dynamics and Regulation of Neurovascular Structure and Function
This project explores how special immune cells in the brain, called microglia, interact with blood vessels to keep our brains healthy, especially in conditions like Alzheimer's disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11086068 on NIH RePORTER |
What this research studies
Our brains need a lot of energy, which comes from blood delivered through a complex network of vessels. When these blood vessels don't work well, it can contribute to brain problems and diseases. Microglia are immune cells that live in the brain and respond to injuries and illnesses, but we don't fully understand how they interact with blood vessels. This work aims to uncover the specific roles microglia play in controlling the structure and function of brain blood vessels. We also want to see how other brain cells and specific genes, like TREM2 which is linked to Alzheimer's, influence these important interactions.
Who could benefit from this research
Good fit: Patients with or at risk for conditions like Alzheimer's disease or those who have experienced acquired brain injuries may ultimately benefit from the knowledge gained from this fundamental research.
Not a fit: Patients seeking immediate treatment options or direct clinical trial participation would not find direct benefit from this basic science project.
Why it matters
Potential benefit: Understanding these interactions could lead to new ways to protect brain health and develop treatments for conditions like Alzheimer's disease and acquired brain injuries.
How similar studies have performed: While preliminary data suggest important interactions, the specific roles of microglia in regulating brain blood vessels are still poorly understood, making this a novel area of exploration.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Eyo, Ukpong Bassey — University of Virginia
- Study coordinator: Eyo, Ukpong Bassey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.