How brain immune cells affect memory and learning
Microglial remodeling of the extracellular matrix in memory circuits
This study is looking at how special immune cells in the brain help shape the connections that support our memory, and it aims to find out how problems with these cells might be linked to memory issues like those seen in Alzheimer's disease, which could lead to new treatments for people with cognitive challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11220792 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, the immune cells in the brain, in the remodeling of the extracellular matrix that supports memory circuits. By examining how these cells interact with neurons and influence synaptic plasticity, the study aims to understand the underlying mechanisms of memory formation and cognitive function. The researchers will use advanced imaging techniques and genetic models to explore how disruptions in this process may contribute to conditions like Alzheimer's disease. Patients may benefit from insights that could lead to new therapeutic strategies for cognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with cognitive disorders unrelated to Alzheimer's disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance memory and cognitive function in patients with Alzheimer's disease and other cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Molofsky, Anna V — University of California, San Francisco
- Study coordinator: Molofsky, Anna V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.