How brain immune cells affect memory and learning
Microglial remodeling of the extracellular matrix in memory circuits
This study is looking at how brain immune cells called microglia help shape the support system for memory and how problems with this process might be linked to memory issues in conditions like Alzheimer's disease, so it’s for anyone interested in understanding more about memory and brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10954261 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, the immune cells in the brain, in the remodeling of the extracellular matrix that supports memory circuits. It focuses on how these cells interact with neurons and contribute to the brain's ability to adapt and form long-term memories. By studying specific signaling pathways involving the cytokine IL-33, the research aims to understand how disruptions in these processes may lead to cognitive disorders, particularly in conditions like Alzheimer's disease. The approach includes detailed structural analyses and behavioral assessments in animal models to uncover the mechanisms behind memory formation and retention.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with cognitive disorders unrelated to Alzheimer's disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving memory and cognitive function in patients with Alzheimer's disease and other cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in cognitive function, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Molofsky, Anna V — University of California, San Francisco
- Study coordinator: Molofsky, Anna V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.