How brain development is influenced by alternative splicing and epigenetic regulation
Alternative Splicing Directed Epigenetic Regulation in Brain Development
This study is looking at how a protein called DPF2 changes during brain development and how these changes help control the growth of brain cells, which could help us understand more about how our brains develop and work.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11039636 on NIH RePORTER |
What this research studies
This research investigates the role of alternative splicing in the regulation of brain development. It focuses on how a specific protein, DPF2, changes its form during brain development and how this affects the regulation of genes involved in neuron formation. By using advanced techniques like CRISPR/Cas9, the researchers aim to understand the mechanisms behind these changes and their impact on neuronal maturation. This could provide insights into the fundamental processes that govern brain development and function.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals with developmental brain disorders or those interested in the biological mechanisms of brain development.
Not a fit: Patients with fully developed brains and no neurological concerns may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing developmental brain disorders.
How similar studies have performed: Other research has shown promising results in understanding the role of splicing in brain development, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Nazim, Mohammad — University of California Los Angeles
- Study coordinator: Nazim, Mohammad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.