How brain damage affects swallowing in Parkinson's disease
Official title: Impact of nigral and extranigral neurodegeneration on aerodigestive discoordination in a pesticide model of Parkinson's disease
Funded at Rowan University School/osteopathic Med · NIH-10769596 · Data updated 2026-11-12
This study is looking into the swallowing problems that many people with Parkinson's disease face, hoping to find out how changes in different parts of the brain affect these issues, so we can discover better ways to help improve swallowing for those who struggle with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University School/osteopathic Med NIH-funded |
| Lab location | 1 site (Stratford, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $390,823 |
| NIH project number | 1R01ES035118-01A1 |
| Project ID | NIH-10769596 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience swallowing difficulties.
✕Less likely to help
Patients with Parkinson's disease who do not have swallowing problems may not benefit from this research.
What this research studies
This research investigates the swallowing difficulties experienced by patients with Parkinson's disease, which affect 90% of individuals and significantly impact their quality of life. The study aims to understand how neurodegeneration in different brain regions, beyond the commonly affected areas, contributes to these swallowing problems. By using animal models, the researchers will compare various aspects of feeding coordination to identify specific dysfunctions that are resistant to current treatments. This approach may reveal new targets for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for swallowing difficulties in Parkinson's disease, enhancing patients' quality of life.
How similar studies have gone: While there has been research on swallowing difficulties in Parkinson's disease, this specific approach focusing on neurodegeneration outside the substantia nigra is relatively novel.
Where this research is happening
-
Rowan University School/osteopathic Med
Stratford, United States Active
Researchers
- Principal investigator: Gould, Francois — Rowan University School/osteopathic Med
- Study coordinator: Gould, Francois
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.