How brain coverings respond in health and migraine
Response Properties of Meningeal Afferents in Health and Migraine
This study is looking at how certain nerve fibers in the brain's protective layers react to different sensations, both when everything is normal and during migraine attacks, to help us understand migraines better and find new ways to treat them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10909315 on NIH RePORTER |
What this research studies
This research investigates the sensory functions of meningeal afferents, which are nerve fibers that innervate the protective coverings of the brain. Using advanced imaging techniques, the study aims to observe how these afferents respond to various stimuli in both healthy conditions and during migraine episodes. By monitoring the activity of these nerve fibers in awake mice, researchers hope to uncover the mechanisms that trigger migraines and the normal sensory functions of these afferents. This could lead to a better understanding of migraine pathology and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience migraines or have a history of migraine headaches.
Not a fit: Patients who do not suffer from migraines or related cranial pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for migraine sufferers by identifying new therapeutic targets.
How similar studies have performed: Other research has shown promise in understanding the role of sensory neurons in migraine, but this approach using advanced imaging techniques is relatively novel.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Levy, Dan — Beth Israel Deaconess Medical Center
- Study coordinator: Levy, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.