How brain connections control fear responses
Synaptic and neuronal mechanisms of fear control: the role of hippocampal-amygdalar interactions
This study is looking at how two parts of the brain, the ventral hippocampus and the amygdala, work together to shape our fear memories and reactions, which could help us find new ways to treat anxiety disorders.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-10809756 on NIH RePORTER |
What this research studies
This research investigates the connections between the ventral hippocampus and the amygdala, focusing on how these pathways influence fear memory and behavior. By using advanced techniques like chemogenetics and optogenetics, the study aims to understand the synaptic and network-level mechanisms that govern fear responses. Patients may benefit from insights into how fear-related behaviors can be modified, potentially leading to new treatments for anxiety disorders. The research involves both animal models and behavioral testing to explore these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals suffering from anxiety disorders or related conditions.
Not a fit: Patients with non-anxiety-related conditions or those not experiencing fear-related behaviors may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing anxiety and fear-related disorders.
How similar studies have performed: Previous research has shown promise in understanding the neural mechanisms of fear and anxiety, suggesting that this approach could yield valuable insights.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Bolshakov, Vadim — Mclean Hospital
- Study coordinator: Bolshakov, Vadim
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.