How brain circuits change after injury in mice
Mechanisms of Somatosensory Circuit Remapping After Cortical Injury in Mice
['FUNDING_CAREER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10874744
This study is looking at how the brain changes and heals itself after an injury, focusing on special nerve cells that help with feeling sensations, and it aims to find ways to improve recovery for people who have had strokes.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10874744 on ClinicalTrials.gov |
What this research studies
This research investigates how the brain's somatosensory circuits reorganize and adapt following injury, specifically focusing on the role of certain types of neurons called GABAergic parvalbumin cells. Using advanced imaging techniques, the study will observe changes in these circuits in live mice after small lesions to the cortex. The goal is to understand how these changes contribute to recovery of sensory functions, which could provide insights into treatments for conditions like stroke.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals recovering from strokes or other neurological injuries that affect sensory function.
Not a fit: Patients with neurological conditions unrelated to circuit remapping or those who have not experienced a cortical injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing recovery in patients who have suffered brain injuries.
How similar studies have performed: Other research has shown promising results in understanding circuit remapping in the brain, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZEIGER, WILLIAM ABEL — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: ZEIGER, WILLIAM ABEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.