How brain circuits affect emotions and defense behaviors
Limbic-midbrain interactions in defense and emotional arousal
['FUNDING_R01'] · GEORGETOWN UNIVERSITY · NIH-10747319
This study looks at how certain parts of the brain work together to control emotions and reactions to stress, using animal models to help us learn more about anxiety disorders in people.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | GEORGETOWN UNIVERSITY (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-10747319 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between different brain regions involved in emotional responses and defense behaviors, particularly focusing on the hindbrain and midbrain circuits. By using advanced imaging techniques and animal models, the study aims to understand how these circuits function in non-human primates, which may provide insights applicable to human anxiety disorders. The research seeks to fill knowledge gaps regarding the organization of these circuits and their role in emotional reactivity and social behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing anxiety disorders, particularly those who have not responded well to existing treatments.
Not a fit: Patients with anxiety disorders who are not willing or able to participate in research involving animal models may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for anxiety disorders by targeting specific brain circuits involved in emotional regulation.
How similar studies have performed: Previous research has shown promising results in understanding brain circuits in rodent models, but this approach in non-human primates is relatively novel.
Where this research is happening
WASHINGTON, UNITED STATES
- GEORGETOWN UNIVERSITY — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MALKOVA, LUDISE — GEORGETOWN UNIVERSITY
- Study coordinator: MALKOVA, LUDISE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.